Constructional Volcanic Edifices on Mercury: Candidates and Hypotheses of Formation

Mercury, a planet with a predominantly volcanic crust, has perplexingly few, if any, constructional volcanic edifices, despite their common occurrence on other solar system bodies with volcanic histories. Using image and topographical data from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, we describe two small (< 15 km‐diameter) prominences with shallow summit depressions associated with volcanically flooded impact features. We offer both volcanic and impact‐related interpretations for their formation, and then compare these landforms with volcanic features on Earth and the Moon. Though we cannot definitively conclude that these landforms are volcanic, the paucity of constructional volcanic edifices on Mercury is intriguing in itself. We suggest that this lack is because volcanic eruptions with sufficiently low eruption volumes, rates, and flow lengths, suitable for edifice construction, were highly spatiotemporally restricted during Mercury's geological history. We suggest that volcanic edifices may preferentially occur in association with late‐stage, post‐impact effusive volcanic deposits. The ESA/JAXA BepiColombo mission to Mercury will be able to investigate further our candidate volcanic edifices, search for other, as‐yet unrecognized edifices beneath the detection limits of MESSENGER data, and test our hypothesis that edifice construction is favored by late‐stage, low‐volume effusive eruptions

Day-length is central to maintaining consistent seasonal diversity in marine bacterioplankton

Marine bacterial diversity is vast, but seasonal variation in diversity is poorly understood. Here we present the longest bacterial diversity time series consisting of monthly (72) samples from the western English Channel over a 6 year period (2003-2008) using 747,494 16SrDNA-V6 amplicon-pyrosequences. Although there were characteristic cycles for each phylum, the overall community cycle was remarkably stable year after year. The majority of taxa were not abundant, although on occasion these rare bacteria could dominate the assemblage. Bacterial diversity peaked at the winter solstice and showed remarkable synchronicity with day-length, which had the best explanatory power compared to a combination of other variables (including temperature and nutrient concentrations). Day-length has not previously been recognised as a major force in structuring microbial communities

Valuing the biodiversity gains from protecting native plant communities from bitou bush (Chrysanthemoides monilifera subsp rotundata (DC.) T.Norl.) in New South Wales: application of the defensive expenditure method

Valuation of the gains from protection of biodiversity is difficult because the services that provide the benefits do not normally pass through markets where prices can form. But the services sometimes pass through markets where consumers or producers behave in a market-oriented manner, and so the values implicit in this behaviour can be identified and derived. Estimates of the benefits of biodiversity protection are derived from the costs of protecting native plant communities from a major weed in Australia, by following this approach. In 1999, invasion of coastal areas of New South Wales by bitou bush (Chrysanthemoides monilifera subsp. rotundata (DC.) T. Norl.) was listed as a key process threatening native plants under the NSW Threatened Species Conservation Act 1995. In accordance with the Act, the Department of Environment and Climate Change prepared a Threat Abatement Plan (TAP) to reduce the impacts of bitou bush on biodiversity at each threatened site. The costs of protecting sites vary closely with the number of priority native species and communities at each site. Following standard economic assumptions about market transactions, these costs are interpreted to provide values the benefits of protecting extra species, communities, and sites. Key words: Bitou bush, Chrysanthemoides monilifera, threat abatement plan, valuation of biodiversity, benefit-cost analysis, weed control, defensive-expenditure method.Bitou bush, Chrysanthemoides monilifera, threat abatement plan, valuation of biodiversity, benefit-cost analysis, weed control, defensive-expenditure method, Demand and Price Analysis, Environmental Economics and Policy,

Eradication of Exotic Weeds in Australia: Comparing Effort and Expenditure

Weeds have many adverse impacts on agriculture and the environment and therefore are often targets of eradication attempts. Eradication attempts involve large commitments of labour and financial resources over significant periods of time. Using data from 12 Australian weed eradication attempts the authors compare work hours and expenditure on each attempt for various initial-infestation sizes. Analysis of a limited data set shows: (1) that while the eradication effort increases with the initial area of infestation, the effort applied per hectare actually decreases; (2) that application of a greater work effort was not the reason why completed eradications were successful; and (3) that the larger the initial infestation size, the smaller the amount of resources applied per hectare for eradication.weeds, eradication, work effort, expenditure, infestation size, Environmental Economics and Policy, Resource /Energy Economics and Policy,

The characterization, management, and future considerations for ErbB-family TKI-associated diarrhea.

PurposeDiarrhea is recognized as a common adverse event associated with tyrosine kinase inhibitors (TKIs), with those targeting the ErbB family of receptors being associated with the highest rate of diarrhea.MethodsThis paper reviews data on the incidence, timing, and duration of diarrhea associated with US Food and Drug Administration-approved ErbB family-targeted TKIs from the published literature, and sets forth recommendations for management.ResultsIn the absence of anti-diarrheal prophylaxis the incidence of any-grade diarrhea varies and typically occurs early during the course of treatment. Although it is difficult to determine if the incidence and severity of diarrhea is related to inhibition of a particular kinase target because of the multi-targeted and overlapping activity of many agents, evidence suggests that second-generation TKIs with broader target profiles (i.e., afatinib, lapatinib, neratinib) result in a higher incidence of diarrhea compared with highly specific first- (erlotinib, gefitinib) or third- (osimertinib) generation agents. The mechanisms responsible for TKI-associated diarrhea are not fully understood and are likely multi-factorial, involving dysregulated ion transport, inflammation, and mucosal injury. Management strategies have been developed-and continue to be refined-to prevent and reduce the severity and duration of TKI-associated diarrhea. For agents associated with more significant symptoms, anti-diarrheal prophylaxis reduces the incidence and severity of diarrhea, and ongoing studies are evaluating specific strategies to further reduce incidence and duration of TKI-associated diarrhea.ConclusionsContinued investigations into risk factors and pharmacogenomic markers for diarrhea may further improve management of this common toxicity

Genetics and Genomic Regions Affecting Response to Newcastle Disease Virus Infection under Heat Stress in Layer Chickens.

Newcastle disease virus (NDV) is a highly contagious avian pathogen that poses a tremendous threat to poultry producers in endemic zones due to its epidemic potential. To investigate host genetic resistance to NDV while under the effects of heat stress, a genome-wide association study (GWAS) was performed on Hy-Line Brown layer chickens that were challenged with NDV while under high ambient temperature to identify regions associated with host viral titer, circulating anti-NDV antibody titer, and body weight change. A single nucleotide polymorphism (SNP) on chromosome 1 was associated with viral titer at two days post-infection (dpi), while 30 SNPs spanning a quantitative trait loci (QTL) on chromosome 24 were associated with viral titer at 6 dpi. Immune related genes, such as CAMK1d and CCDC3 on chromosome 1, associated with viral titer at 2 dpi, and TIRAP, ETS1, and KIRREL3, associated with viral titer at 6 dpi, were located in two QTL regions for viral titer that were identified in this study. This study identified genomic regions and candidate genes that are associated with response to NDV during heat stress in Hy-Line Brown layer chickens. Regions identified for viral titer on chromosome 1 and 24, at 2 and 6 dpi, respectively, included several genes that have key roles in regulating the immune response

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.

Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota NDV strain at 21 days of age. Through transcriptome analysis, gene expression in spleen at 2 and 6 days post-inoculation was compared between NDV-infected and control groups, as well as between chicken lines. At a false discovery rate &lt;0.05, Fayoumi chickens, which are relatively more resistant to NDV, showed fewer differentially expressed genes (DEGs) than Leghorn chickens. Several interferon-stimulated genes were identified as important DEGs regulating immune response to NDV in chicken. Pathways predicted by IPA analysis, such as "EIF-signaling", "actin cytoskeleton organization nitric oxide production" and "coagulation system" may contribute to resistance to NDV in Fayoumi chickens. The identified DEGs and predicted pathways may contribute to differential responses to NDV between the two chicken lines and provide potential targets for breeding chickens that are more resistant to NDV